Leukocytosis and Spurious Hypoxemia

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Blood oxygenation and spurious hypoxemia

In health pO2(a) is maintained within the range 10.613.3 kPa (80-100 mmHg) and hypoxemia (reduced blood oxygen) is diagnosed if pO2(a) is less than 10.6 kPa (80 mmHg). The purpose of this article is to highlight the spurious severe hypoxemia that occurs in patients with particularly high white-cell count or high platelet count. In these patients there is a marked discrepancy between measured (i...

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Hypoxemia During Extreme Hyperleukocytosis: How Spurious?

BACKGROUND Spurious hypoxemia has been described in case reports during extreme hyperleukocytosis and has led to recommendations for immediate cooling and analysis of arterial blood gases (ABGs). We sought to determine, in samples processed as recommended, the magnitude of spurious hypoxemia in acute leukemia subjects with hyperleukocytosis. METHODS A retrospective chart review was conducted ...

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Explanation for apparent hypoxemia associated with extreme leukocytosis: leukocytic oxygen consumption.

We investigated the hypoxemia associated with extreme leukocytosis in leukemic patients. In vitro experiments showed that the rate of decrease in the partial pressure of oxygen in the blood samples from such patients was proportional to the white cell count. In the presence of normal white cell count no drop in PO2 was observed. We conclude that a low arterial oxygen tension in the presence of ...

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Hypoxemia

تنفس یکی از اساسی ترین نیازهای انسان است که در صورت عدم تأمین این نیاز، حیات انسان چند دقیقه ای بیشتر ادامه نخواهد یافت. اهمیت این فعالیت حیاتی از تأثیر آن بر تغذیه سلولها به عنوان کوچکترین واحد سازنده بدن انسان نشأت می گیرد، زیرا اکسیژن یکی از مواد ضروری برای سلولها می باشد و کسب این ماده حیاتی فقط از طریق تنفس مناسب و راحت امکان پذیر است .

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Spurious Hyperleukocytosis

Hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. Nucleated RBCs give rise to spuriously high total leucocyte count and cause clinical dilemma. Thalassemia major patients are known to have leucocytosis even after correction for nucleated RBCs. We report a case of undiagnosed Thalassemia major in a 4 month old infant with total leucocyte count highe...

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ژورنال

عنوان ژورنال: Cureus

سال: 2021

ISSN: 2168-8184

DOI: 10.7759/cureus.15942